Hill's Equation by Wilhelm Magnus download in iPad, ePub, pdf
Positive cooperativity refers to the fact that the binding of one substrate facilitates the binding of another substrate to the protein. This is because it takes a very small amount i. The Hill coefficient, named for Archibald Vivian Hill, provides a way to quantify this effect. Optionally, the units may also be entered in the cells available. The catch mechanism is a solenoid.
Any unit label entered will be added to the title for the corresponding axis. Vmax is the maximum velocity of the reaction. As the substrate concentration increases further, small increases in the substrate concentration lead to large increases in the reaction rate.
For hyperbolic reactions, when the substrate concentration is low, the reaction rate increases almost in a linear fashion with increasing substrate concentration. It may also be referred to as Khalf. In biochemistry, the binding of a ligand to a macromolecule is often enhanced if there are already other ligands present on the same macromolecule this is known as cooperative binding. It provides a measure of the cooperativity of substrate binding to the enzyme, transporter, etc. Digression to point out the gamma fiber feedback of muscle tension by Golgi tendon organ and the Ia fiber length change detector wrapped around the muscle spindle, or intrafusal muscle fiber.
The Hill coefficient is unitless. Reactions that exhibit a sigmoidal curve also exhibit saturation at high substrate concentration see Fig.